Question

Which common adverse effect may occur with the combination of

spironolactone and hydrochlorothiazide? select all that apply
A.hyperkalemia
B. hyperglycemia
C. hyponatremia
D. hyperuricemia
E. orthosta

Answer 1

The combination of spironolactone and hydrochlorothiazide can lead to hyperkalemia, hyponatremia, and orthostatic hypotension as common adverse effects.

Step-by-step explanation:

The common adverse effect that may occur with the combination of spironolactone and hydrochlorothiazide includes hyperkalemia, hyponatremia, and orthostatic hypotension.

Hyperkalemia: Spironolactone is a potassium-sparing diuretic, meaning it helps the body retain potassium. When combined with hydrochlorothiazide, which is a thiazide diuretic that increases sodium excretion, hyperkalemia (high potassium levels) may occur.

Hyponatremia: Thiazide diuretics like hydrochlorothiazide can increase the excretion of sodium, leading to low sodium levels in the blood (hyponatremia).

Orthostatic hypotension: Orthostatic hypotension is a drop in blood pressure when changing positions, such as from lying down to standing up. It can be a potential adverse effect of both spironolactone and hydrochlorothiazide.