Final answer:
Most antitumor antibiotics, like daunorubicin and doxorubicin, are classified as vesicants due to their potential to cause severe tissue injury if they leak from veins during administration.
Step-by-step explanation:
Most antitumor antibiotics are considered to be vesicants. Antitumor antibiotics such as anthracyclines, which include daunorubicin (Cerubidine®) and doxorubicin (Adriamycin®), work by binding to DNA, preventing RNA synthesis and causing DNA strand breakage. These compounds are often vesicants, which means they can cause severe tissue injury if they escape from the vein during intravenous infusion. Such injury can lead to blistering, severe cellular damage, and necrosis, which is why safe administration techniques are paramount when delivering these agents.