Question

Which autoantibodies are associated with systemic sclerosis (scleroderma) and are commonly used for diagnosis and classification of the disease?

A) Anti-Sm antibodies
B) Anti-Ro antibodies
C) Anti-Scl-70 antibodies
D) Anti-CCP antibodies

Answer 1

The correct autoantibodies associated with systemic sclerosis for diagnosis and classification are Anti-Scl-70 antibodies.

Step-by-step explanation:

The autoantibodies associated with systemic sclerosis (scleroderma) that are commonly used for diagnosis and classification of the disease are C) Anti-Scl-70 antibodies. While Anti-Sm antibodies are associated with Systemic Lupus Erythematosus (SLE), Anti-Ro antibodies are also seen in SLE and Sjögren's syndrome, and Anti-CCP antibodies are associated with Rheumatoid Arthritis. Systemic sclerosis involves a humoral immune response where the body produces autoantibodies against its own tissues, leading to tissue damage and scar formation.