Final answer:
All provided options apply to the Jamestown Colony. The colonists aimed to become wealthy, faced hardships due to inexperience and work aversion, suffered from malaria due to the settlement's location, and were led by John Smith during critical periods of their early history.
Step-by-step explanation:
The Jamestown Colony represents a significant chapter in American history, with its establishment as the first permanent English settlement in North America. Settlers indeed came to get rich, which applies to option (a), driven by economic prospects chiefly surrounding the cultivation of tobacco as a cash crop after initial failures in finding gold.
Challenges that they faced related to inexperience in agriculture and reluctance to work are true, making option (b) accurate. These struggles were compounded as the settlement was indeed built near a swampy area that was a breeding ground for mosquitoes carrying Malaria, confirming the correctness of option (c).
Lastly, John Smith was a critical leader in the colony's early years, which makes option (d) correct as well. Therefore, all options a, b, c, and d apply to the Jamestown Colony.