Final answer:
The ORC binds to specific nucleotide sequences called origins of replication to assemble the pre-RC that is competent to initiate replication.
Step-by-step explanation:
The ORC (origin recognition complex) binds to specific nucleotide sequences called origins of replication to assemble the prereplication complex (pre-RC) that is competent to initiate replication. In prokaryotes, such as E.coli, the ORC recognizes the 245 base pair-long origin of replication, which is rich in adenine-thymine (AT) sequences. In eukaryotes, multiple origins of replication exist on the chromosome, and the ORC binds to these origins to initiate replication.