Final answer:
The rule that informed consent must be obtained flows from the principle of autonomy in the Belmont Report. correct option is d.
Step-by-step explanation:
The rule that informed consent must be obtained flows from the principle of autonomy in the Belmont Report. The principle of autonomy states that patients have a right to exercise agency or self-determination when making decisions about their own health care.
In clinical trials, informed consent is necessary to protect the autonomy and rights of participants and to prevent exploitation.