Final answer:
The nurse should instruct the client to take extended-release oxycodone with a full glass of water and not to crush, chew, or cut the tablet to maintain its extended-release properties and prevent potential overdose.
Step-by-step explanation:
The nurse should include the following statement in the teaching for a client with a new prescription for extended-release oxycodone: "Take the medication with a full glass of water." Oxycodone extended-release tablets and capsules are formulated to release the medication gradually over time to provide prolonged pain relief. Therefore, it is crucial that the client does not crush, chew, or cut the tablet. Crushing, chewing, or cutting can lead to a rapid release of the medication, causing potential overdose and serious health consequences. Additionally, altering the tablet can negate the extended-release properties, leading to inadequate pain management.