Question

How does the binding of estrogen to the estrogen receptor lead to binding of the p160 co-activator?

- It causes helix 12 to roll in such a way that exposes the binding pocket for a helix of p160.
-It causes the SMRT complex to release from the estrogen receptor.
-It causes the helix 10 of p160 to have increased affinity for the ligand binding site.
-It causes Hsp90 to lose affinity for the nuclear localization sequence.

Answer 1

When estrogen binds to the estrogen receptor, it causes an allosteric change in the receptor that releases the Hsp90 protein, allowing the receptor to bind to a DNA sequence and trigger gene transcription.

Step-by-step explanation:

When estrogen binds to the estrogen receptor, it causes an allosteric change in the receptor that leads to the release of the Hsp90 protein. This allows the receptor to translocate to the nucleus and bind to a DNA sequence called a hormone response element (HRE), which triggers gene transcription and translation. The corresponding protein product can then mediate changes in cell function.