Question

What do SHP-1 and IL-10 have in common with regard to B-cell function?

A. Both exert negative regulation of B-cell activity.
B. Both exert positive regulation of B-cell activity.
C. Both are B-cell survival factors.
D. Both induce B-cell proliferation.
E. None of the above

Answer 1

Both SHP-1 and IL-10 exert negative regulation of B-cell activity.

Step-by-step explanation:

Both SHP-1 and IL-10 exert negative regulation of B-cell activity. SHP-1 is a protein tyrosine phosphatase that acts as a negative regulator of signaling pathways in B cells. It inhibits B-cell receptor signaling and dampens B-cell activation.

IL-10, on the other hand, is an anti-inflammatory cytokine that suppresses the function of B cells. It inhibits B-cell proliferation, antibody production, and class switching.

Therefore, the correct answer is A. Both exert negative regulation of B-cell activity.