Final answer:
The inner monolayer of the transport vesicle facing the cytosol before fusion becomes the cytosolic-facing monolayer of the plasma membrane when the vesicle fuses with it.
When the transport vesicle shown here fuses with the plasma membrane, which monolayer will face the cell cytosol? cytoplasmic monolayer
Step-by-step explanation:
When the transport vesicle fuses with the plasma membrane, the monolayer that will face the cell cytosol is the one that was facing the inside (or cytosolic side) of the vesicle before it fused with the plasma membrane. Typically, vesicles move material from one part of the cell to another or to the outside of the cell, as in secretory vesicles releasing contents into the extracellular space through exocytosis.
As vesicles move through the endomembrane system, their orientation is preserved, so the inner surface of the transport vesicle becomes continuous with the cytosolic side of the plasma membrane upon fusion.