Final answer:
The bent conformation of integrins is typically seen as inactive. Activation occurs when conformational changes, such as binding to talin in focal adhesions, allow integrins to interact with the extracellular matrix.
Step-by-step explanation:
The conformation of integrins can be either bent or extended, which relates to their activity state. Typically, the bent confirmation of integrin is considered to be the inactive form, while the extended conformation represents the active state capable of binding to the extracellular matrix (ECM). When talin binds to integrins, primarily in the cell's focal adhesions, this interaction can lead to an activation of the integrin and therefore strengthen the cell's adhesion to the ECM. The activation process involves conformational changes that propagate through the integrin which translates extracellular contacts into intracellular signaling pathways, crucial for a variety of cellular processes, including cell migration, cell shape, and the mechanical stability of tissues.