One potential theme for Gris Grimly's Frankenstein could be the danger of ambition and the pursuit of knowledge. Throughout the novel, we see the consequences of Victor Frankenstein's unrelenting ambition to create life, and the devastating effects it has on both himself and those around him. By choosing this theme, you could analyze how the novel critiques the dangers of unchecked scientific progress and the ethical considerations that come with it. You could also explore how the theme of ambition and the pursuit of knowledge is relevant in contemporary society, and how the cautionary tale of Frankenstein can provide important insights into our current technological and scientific advancements.