Question

2. Why might a manufacturer choose one binder over another? Describe three possible reasons.

Answer 1

Explanations:

1) The formula for calculating the number of moles of a molecule is expressed as:

`\text{number of moles =}\frac{number\text{ of molecules}}{6.02*10^(23)^{}}`

For Sucrose:

`\begin{gathered} moles\text{ of sucrose=}(2.0*10^(34))/(6.02*10^(23)) \\ moles\text{ of sucrose=}0.3322*10 \\ moles\text{ of sucrose}=3.322\text{moles} \end{gathered}`

Mass of sucrose = Moles * Molar mass

Mass of sucrose = 3.322 * 342.3g/mol

Mass of sucrose = 1,137.1206rams

Mass of sucrose in mg = 1,137,120.6mg

For Potassium sorbate

`moles\text{ of potassium sorbate=}(2.0*10^(34))/(6.02*10^(23))`

Mass of potassium sorbate = Moles * Molar mass

Mass of potassium sorbate = 3.322 * 150.22 g/mol

Mass of potassium sorbate = 499.03084grams

Mass of potassium sorbate in mg = 499,030.84mg

For corn starch

Mass of corn starch = moles * Molar mass

Mass of corn starch = 3.322 * 692.7g/mol

Mass of corm starch = 2,301.1494grams

Mass of corm starch in mg = 2,301,149.4mg

The mass of each binder differs due to the type and amount of element each binder contains. Also, the molar mass of each of the binders differs. These differences in their molar mass cause a difference in the mass of each binder.

2) Manufacturers can decide to choose one binder over another due to the following reasons;

i) The binder must be easily compressible. Compressibility is required to form a stable, intact, and compact mass when pressure is applied

ii) The binder must have consistent weight and uniform strength. This is important in measuring the fluidity necessary for the production of the tablet.

iii) Since the essence of adding a binder to powder that is to be granulated is as a solution, hence the manufacturer must also check the particle size, hydrophobicity, and solubility in the binders since they are all important in assessing granulation.