Question

58.The best description of the induced fit model of enzyme function isa. a cofactor must first bind to the active site, allowing the substrate to fit properly.b.a molecule not directly involved in the catalysis interacts with a site on the proteinfar from the active site, changing the shape of the active site to make it work.c. the active site, the substrate, or both change shape upon binding so that theactivation energy of the desired change is decreased.d. the active site has a definite, rigid shape that only fits one substrate molecule.a short protein chain that blocks access to the active site is chemically removed asthe substrate approaches.

Answer 1

The correct answer is C:

the active site, the substrate, or both change shape upon binding so that the activation energy of the desired change is decreased.

The induced fit model for enzymed function describes how the substrate is able to induce the proper alignment of the active site of the enzyme. Both the active site of the enzyme and the substrate change in conformation until they are completly bound.

This theory explains why enzymes may exhibit broad specificity, that is that they can bind to a variety of molecules.