Question

A ligand cannot bind to the active site of an enzyme.
a. True
b. False

Answer 1

A ligand can bind to the active site of an enzyme. However, an allosteric inhibitor can bind to an enzyme away from the active site, causing a conformational change in the active site that decreases its affinity for the substrate.

Step-by-step explanation:

A ligand can bind to the active site of an enzyme. The active site is a specific region on the enzyme where the substrate binds, leading to the catalysis of a biochemical reaction. However, an allosteric inhibitor can also bind to an enzyme but away from the active site, causing a conformational change in the active site. This change decreases the affinity of the active site for the substrate, inhibiting the enzyme's activity.

Answer 2

Hey there Charles5373!!
The correct choice would be False because it can bind. Competitive inhibitors can bind to the active site. Since it is not converted to product by the enzyme it would be considered to be a ligand. The substrate also binds to the active site, but it is converted to product.
Hope this helped and have a great day!! (: