Answer:
When there is a sufficient cortisol level in the body.
Step-by-step explanation:
Corticotropin-releasing factor (CRF) is a hormone synthesized in the hypothalamus, whose function is the release of adrenocorticotropic hormone (ACTH), also called corticotropin, by the adenohypophysis. The stimuli for the release of CRF converge to the median eminence, leading to their secretion in the pituitary vessels, on the other hand, when the release of cortisol in the organism is high and its concentration is at a significant level, the release of CRF is interrupted.