Question

Budding yeast cells that are deficient for mad2, a component of the metaphase checkpoint, are killed by treatment with benomyl, which causes microtubules to depolymerize. in the absence of benomyl, however, the cells are perfectly viable. explain why mad2-deficient cells live in the absence of benomyl but die in its presence.

Answer 1

Without benomyl, the larger part of axles shape ordinarily and the axle connection checkpoint assumes no part. As a result, Mad2 is immaterial. Within the sight of benomyl, notwithstanding, cells that are damaged for Mad2 can't stop cell-cycle movement, with the outcome that chromosomes are isolated erroneously, making the cells pass on.