533,100 views
12 votes
12 votes
Sickle Cell Anemia is a disease caused by a recessive allele. What is the chance a child will have Sickle Cell (is affected by the disease) if one parent has it, and the other parent does not and is homozygous?A. 75%B. 100%C. 33%D. 0%

User Moumou
by
2.6k points

1 Answer

9 votes
9 votes
Step-by-step explanation:

Remember that In autosomal recessive inheritance, the pathological allele is recessive. Let us denote by "a" the pathological recessive allele.

Autosomal recessive inheritance means that the genetic condition occurs when the child inherits two copies of a mutated gene (one copy from each of the two parents), that is, has two copies of the disease gene. In general, neither the mother nor the father has the condition, they are called carriers because they each have a copy of the mutated gene and can pass it on to their children.

Now, according to the problem, one parent has an autosomal recessive disease (Sickle Cell Anemia ), that is, this parent is an affected patient or in other words, this parent is homozygous for the pathological allele (aa), and the other parent does not have the disease and is homozygous (AA) but not for the pathological allele.

Then, we get the following Punnet Square:

This means that 100% of individuals of the offspring are carriers but none of them are affected; that is 0% of the individuals of the offspring do not have the condition but instead are carriers since do not have both recessive genes.

We can conclude that the correct answer is:

Answer:

0%

Sickle Cell Anemia is a disease caused by a recessive allele. What is the chance a-example-1
User Duarte Meneses
by
2.5k points