Final answer:
The number of little cubes with paint on at least one side is 16.
Step-by-step explanation:
To find out how many little cubes have paint on at least one of their sides, we need to calculate the surface area of the big cube and then divide it by the surface area of each little cube. The surface area of the big cube is 6 times the area of one face, which is 10x10 = 100 square inches. The surface area of each little cube is 6 square inches. So the number of little cubes with paint on at least one side is 100 divided by 6, which is approximately 16.67. Since we can't have a fraction of a cube, the answer is 16 little cubes.