Andrew Jackson was particularly interested in the relocation of American Indians. Presidents before Jackson had usually prefered to intervene as little as possible, even those who believed in assimilation. However, Jackson took a strong approach towards removal.
Jackson advocated for Indian removal to the west, to the lands that were not part of any state. He wanted to keep the lands in the east for the use of the European population. This led him to sign the Indian Removal Act in 1830. The Act led to enormous suffering among the Indian population, including the Cherokee's removal in what is now known as the "Trail of Tears."