Answer and Explanation:
The big difference between the Hamiltonian Federalists and the Jeffersonian Republicans lies in the way in which each group believed that the country should be governed and who should govern.
On the one hand, the Hamiltonian Federalists wanted the creation of a strong central government, with a power greater than the power of the states. Furthermore, they believed that owners with a large academic background should rule the country.
On the other hand, the Jefersonian Republicans believed that the existence of a central government would be beneficial, but that most of this power should stay with the states. Furthermore, they believed that the common man should rule the nation.