The March is called the Trail of Tears because many natives were relocated from their homelands in the South to the West areas, near the Mississippi River. Government authorities were in charge of carrying out those forced relocations and so many died during the March (option A). Many of the relocated peoples died before reaching their destinations due to starvation, disease and any bad and hard conditions they suffered during the trip.
The removals included members of the Cherokee, among other nations such as Choctaw, Ponca, Winnebago. Thus, the concept Trail of Tears clearly makes reference to the forced removal of Native American Tribes and its consequences, mainly during 1838.