The virophages require a bigger virus to double themselves known as the host-virus. They are devoid of the genes for proteins required to double themselves and are always smaller in comparison to archaea and bacteria. On the other hand, in viruses, the genetic information can be in the form of RNA or DNA.
Both the virophages and viruses possess a protein capsid enveloping their nucleic acid. Both the forms do not belong to any of the three domains, and they cannot replicate on their own. Neither the virophages nor the viruses produce energy via mitochondria.