The correct answers are A) Interstate Commerce Commission and C) Pure food and drug act.
Teddy Roosevelt had a hand in these domestic issues during his presidency: Interstate Commerce Commission and C) Pure food and drug act.
The domestic program created by United States President Theodore Roosevelt was called "The Square Deal." The program focused on three important elements: the conservation of natural resources and taking care of the environment, consumer protection, and the control of corporations. He wanted to help the middle class in the US and combat corruption practices. So yes, Teddy Roosevelt had a hand in these domestic issues during his presidency: Interstate Commerce Commission and Pure food and drug act, that later established the Food and Drug Administration.