The correct answer is A) Mecca and Medina.
The two holiest cities of Islam are Mecca and Medina.
Islam’s two most important and holiest sites for adoration are Mecca and Medina. Since many thousands of years ago, Muslims from every corner of the world go to Mecca for its pilgrimage. In the city, there is the holiest place for Muslims, the Masjid al-Haram or Sacred Mosque. In 630, the prophet Muhammad declared this place as a place of pilgrimage. Medina is the second most important and holiest place for Muslims. There, pilgrims visit the tomb of Muhammed.