Answer:
It applies to prokaryotes but not to eukaryotes.
Step-by-step explanation:
one-gene/one-polypeptide hypothesis is based on the idea that there is a structurally complex gene whereby each gene encodes a single polypeptide, that either operates on its own or under a relatively more complex protein.
However, based on the existing findings and research, the one-gene/one-polypeptide hypothesis "applies to prokaryotes but not to eukaryotes."
This is because one gene/one-polypeptide cannot be used to explain different spliced versions found in several eukaryote organisms