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A mule is the offspring of a horse and a donkey. a donkey sperm contains 31 chromosomes and a horse egg 32 chromosomes, so the zygote contains a total of 63 chromosomes. the zygote develops normally. the combined set of chromosomes is not a problem in mitosis, and the mule combines some of the best characteristics of horses and donkey. however, a mule is sterile; meiosis cannot occur normally in its testes and ovaries. explain why mitosis is normal in cells containing both horse and donkey chromosomes but the mixed set of chromosomes interferes with meiosis.

User KarlB
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Considering that in meiosis, a diploid parent cell must be split into haploid daughter gametes with equal amounts of chromosomes, it's impossible to split the original 63 chromosomes in half for the first stage of meiosis because the number of chromosomes is odd. Hence, mules cannot carry out meiosis to form gametes with the same number of chromosomes and therefore they cannot produce fertile offspring.
User Ihor Tkachuk
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