Answer:
4. Late-onset menarche
Step-by-step explanation:
Endometrial cancer is the cancer that affects the lining of the uterus with common signs like vaginal bleeding, which is not as a result of menstruation, being noticed among other symptoms.
Several risk factors have been associated to increase the chances of a female having this cancer. Obesity is one of the major risk factors. High-fat diet and hypertension are also risk factors. Late-onset menarche is not a risk factor, rather, early-onset of menarche is. That is, early onset of the first menstrual cycle or first appearance of menstrual bleeding in a female increases the chances of a female of having endometrial cancer, especially considering her family history.