Answer:
hepatotoxicity
Step-by-step explanation:
Even in the low doses used in rheumatoid arthritis , methotrexate can cause hepatotoxicity. It is recommended by many clinicians serial liver biopsies for patients on long-term, low-dose methotrexate.
Hepatotoxicity means chemical-driven liver damage. Drug-induced liver injury is a cause of acute and chronic liver disease. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.