Final answer:
Schizophrenia is most closely linked with excess activity of dopamine receptors, and antipsychotics used for its treatment function as dopamine antagonists to block this activity.
Step-by-step explanation:
Schizophrenia is most closely linked with excess receptor activity for the neurotransmitter dopamine (A). The symptoms of schizophrenia are associated with hyperactive dopamine neurotransmission. Antipsychotic medications often used for treatment are dopamine antagonists, which block dopamine's effects by attaching to its receptors without activating them, limiting the signaling between neurons.
Dopamine dysregulation in schizophrenia is understood to be secondary to GABAergic dysfunction. Yet, most therapeutic strategies focus on targeting dopamine and serotonin receptors due to their crucial role in the disease's pathology. Dysfunctional dopamine signaling is implicated not only in schizophrenia but also in other conditions like depression, bipolar states, and Parkinson's disease, through interaction with other neurotransmitters like glutamate and GABA.