Answer:
tolerance
Step-by-step explanation:
Tolerance is the diminishing effect of a medication by overexposing the patient to its active ingredient. In practice, this translates into increasing dosages of the same drug to achieve the same results commonly related to standard dosages, similar to what is happening with Maurie's drug.
The reduction in patient response to medication is usually related to frequent and regular drug use to the extent that the scale and nature of medication use can be classified as addiction.