Answer:
Most genetic disease result from mutation that causes a gene to produce non functioning Protein.
Step-by-step explanation:
Mutation deals with alteration of nucleotide sequence of the gene that encodes a functional protein product.
As a result of mutation the open reading frame of the mRNA sequence transcribed from that gene is being changed. Due to which the mutated gene can no longer form functional protein. This ultimately leads to production of non functional or truncated protein or disease causing protein.
For examle the Sickle cell anemia is caused due to the mutation in the beta chain of hemoglobin resulting in the accumulation of insoluble aggregates of HbS .