Question

Canine phosphofructokinase (PFK) deficiency afflicts springer spaniels, affecting an estimated 10% of the breed. PFK is the glycolytic enzyme that phosphorylates fructose-1-phosphate and catalyzes the committed step in glycolysis. Given its critical role in glycolysis, one implication of the genetic defect resulting in PFK deficiency in dogs is _____.

Answer 1

intolerance of exercise.

Step-by-step explanation:

Springer spaniels are affected by PFK deficiency i.e canine phosphofructokinase, impacting about 10 percent of the breed. PFK is basically an enzyme known asglycolytic that phosphorylates fructose-1-phosphate and catalyzes glycolysis step.

Considering its crucial role in glycolysis, a consequence of genetic disorder that results in the dog's PFK deficiency is intolerance of exercise.