The correct answer is C. It refers to the departure of grown children from the home.
Step-by-step explanation:
The "empty-nest syndrome" is a term used to refer to the feelings and experience of parents whose children departure from home usually because they have grown up and become independent or are leaving home to attend college or university. The empty-nest syndrome often implies feelings such as grief, stress, sadness or loneliness that can lead to depression although in most cases it just takes some time to parents to adjust to not living with their children. According to this, the option that describes empty-nest syndrome is "It refers to the departure of grown children from the home".