Question

Levofloxacin is a broad-spectrum antibiotic that inhibits DNA gyrase. What is the most likely reason it can kill bacteria.

A. It blocks prokaryotic DNA replication by preventing melting of the DNA double helix at the replication fork B. It blocks prokaryotic DNA replication by preventing unwinding of the super coils in the DNA double helix
C. It interferes with prokaryotic DNA replication by preventing fusion of Okazaki fragments
D. it blocks prokaryotic transcription by preventing unwinding of the DNA double helix during transcriptional initiation
E. it blocks prokaryotic transcription by preventing unwinding of the DNA double helix during transcriptional elongation

Answer 1

The correct answer is option B.

Step-by-step explanation:

Levofloxacin refers to an antibiotic, which fights against the bacteria within the body. It is used in the treatment of various kinds of bacterial infections. DNA gyrase refers to an important bacterial enzyme, which catalyzes the ATP-dependent negative supercoiling of double-stranded closed circular DNA, it comes under the category of topoisomerases, which take part in monitoring the topological transitions of DNA. The antibiotic levofloxacin acts against DNA gyrase and blocks prokaryotic replication of DNA by inhibiting unwinding of the supercoils in the double helix of the DNA.