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When Europeans made contact with Native Americans in the Americas, the most significant impact upon Native Americans was

A. Enriching Native American culture
B. Death by European diseases
C. Conversion to Christianity
D. Discovery of new methods of hunting

User Dvanaria
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B, European settlers were immune to such diseases like smallpox because it came from their region, when knowledge that the native Americans were not immune and the disease was lethal to them, they started distributing blankets and clothing items that were infected with the viruses and caused a major impact on native population

User Architect Jamie
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