Answer: 21600
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Step-by-step explanation:
There are 6 letters to pick from {A,B,C,D,E,F} and we have two slots to fill, where no repeats are allowed. This means we have 6*5 = 30 different ways to pick two letters.
There are 10 digits to pick from {0,1,2,...,9} and there are 3 slots to fill. This gives 10*9*8 = 720 different permutations for this portion.
Overall, we have 30*720 = 21600 different serial numbers possible.