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What is the difference between diffusion of hydrophobic substance in confirmation to hydrophilic ones across the plasma membrane

User Ryan Gates
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The portions of an integral membrane protein found inside the membrane are hydrophobic, while those that are exposed to the cytoplasm or extracellular fluid tend to be hydrophilic. Transmembrane proteins may cross the membrane just once, or may have as many as twelve different membrane-spanning sections.

User SnellyBigoda
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