Desire for more land would mean that these settlers would look at the current inhabitants as temporary, a nuisance to be cleansed. While not all people looked at them this way, this did help rationalize and justify the mass relocation of Native Americans to what is now the west United States. Desire for land also meant that settlers would have to familiarize themselves with America and take record of their surroundings, like plant and animal life and geography, which was an expensive, laborious, dangerous, and time consuming thing to do. For that reason, many settlers had relatively good relations with the Natives, as it gave them the advantage of not having to do all of the necessary research themselves. Of course this did later on lead to mass relocation and arguably mass genocide when the natives became inconvenient, but all in all it really depended on how the Natives reacted to the settlers in the particular area. Take Roanoke for example: an entire settlement vanished for some unknown reason, but it was most likely done by a local Native American tribe that did not appreciate foreigners invading their territory. Also, they are NATIVE AMERICANS, not INDIANS! Indians are from India, so to call Native Americans Indians is not only ignorant, but also incorrect. If you have any other questions, just ask. (I have nothing better to do anyways, I have the week off) Happy Thanksgiving!