Answer:
A transforming principle in the S bacteria allowed the nonvirulent R-strain to become virulent.
Reference:
3.2 Examine the structure of DNA and its function with genetic inheritance
DNA's Structure and Function in Genetic Inheritance READING ASSIGNMENT
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"...the combination of the heat-killed S-strain and the nonvirulent R-strain caused a 'bacterial transformation,' which rendered the combination highly virulent and fatal to the mouse." (PDF pg. 44)
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