Hello. You didn't put the answer options, but we can say that Charles V's empire was considered a political failure because of the constant conflicts with France and the Ottoman Empire, which caused the exhaustion of the kingdom's finances, the establishment of a uncontrolled inflation, the revival of Italian wars and the uncontrollable advance of the Ottoman Empire in central Europe.
All of this made Charles V's government a weak one with more losses than gains. These losses forced him to make a series of abdications in 1556 that further weakened the kingdom.