Question

Researchers are studying the abnormal activity of kinases in relation to cancer. Theoretically, how might researchers use signal transduction pathways to influence the environment of cancer cells for treatment? (3 points)

Disrupt the function of protein kinases involved in cell cycle regulation

Inactivate epinephrine receptors on cancer cells

Stimulate production of cAMP in cancer cells

Alter G protein-coupled receptors involved in cell cycle regulation to be active in the absence of their normal signaling molecules

Answer 1

I am pretty sure that the answer is A.

Step-by-step explanation:

Protein kinases regulate the cell cycle by giving the "go-ahead" or "stop" signal at checkpoints in the cycle. A mutation/disruption in the protein kinases can result in it not doing its job properly. As a result, it can give the 'go-ahead' signal to all cells (mutated or not) to continue through the cell cycle. A distrupted kinase will infleunce the enviornment for a cancer cell as the cancer cell can continue to divide continuously.

I do not think the answer is D because G-couped receptirs are not involed in the regulation of the cell cycle. Additionally, I do not think the answer is C since the production of cAMP (a secondary messgenger amplifies transduction signals; this doesn't have anything to do with cancer?) Finally, between A and B I know that a direct result of cancer is due to a distruption in either protien kinases or growth factors (not in the answer choices). Since one of the factors that leads to cancer is present in answer choice A, I think that is the one. However, this is just my reasoning, I am not 100% sure!