Question

If you want to form a kinetic enolate, you want to:______.A. use a strong, non-nucleophilic base such as LDA.B. use a protic solvent.C. use a low temperature.D. both use a strong, non-nucleophilic base such as LDA and use a low temperature.E. both use a strong, non-nucleophilic base such as LDA and use a protic solvent.F. both use a protic solvent and use a low temperature.

Answer 1

D. both use a strong, non-nucleophilic base such as LDA and use a low temperature.

Step-by-step explanation:

The more stable enolate is the thermodynamic enolate, and a less stable is known as the kinetic enolate.

The less stable enolate has a less substituted product, while the more stable product has a more substituted product.

Now, to form a kinetic enolate, we need to choose a strong, non-nucleophilic base such as LDA to attract hydrogen from the less substituted site. However, an increase in temperature results in an increase in a reaction, which leads to the formation of a stable product.

So, to form the kinetic enolate, a low temperature will be required.

Thus, To form a kinetic enolate, both use a strong, non-nucleophilic base such as LDA and use a low temperature.