Answer:
Correct answer is the Eastern Mediterranean and Middle East.
Step-by-step explanation:
First option is not correct as Venice wasn't opened towards the Atlantic Ocean and actually lost its influence when the New World was discovered.
Second option is also not correct as the connection to this countries went through Atlantic Ocean.
Third option is also not correct for more or less the same reason and because Venice focused on maritime trade, which means that they didn't trade much with them as they as this countries are located in Central Europe.