Answer:
D. The growth of northern industry and regional economic specialization.
Step-by-step explanation:
Antebellum era is the period between War of 1812 and the Civil War. The era is defined by barbaric slavery system in the South. To the North fabric industry was expanding.
The historical developments that contradicted with Jefferson's vision for a republic America based on farms and agriculture. As stated above, Northern states were growing in manufacturing industries which opposes the thought of farming and agriculture. It also opposed the regional economic specialization.
Therefore, option D is correct.