Being a slave in the Southern colonies was exceptionally difficult. The South focused on agriculture, while the North focused on industrialization, so the South needed more labor to deal with their farms.
~The hot climate.
The Southern colonies were known for their very warm weather, this was why they were exceptionally good at agriculture and farming. The warm weather made plants thrive and made the soil rich. While this was good for plantation owners, working as a slave in the hot climate was difficult. Many did not have easy access to water, so would often remain thirsty in the summer heat. They would have to work all day and almost every day as well.
~Cruel overseers.
Many whites in the Southern colonies were prejudiced against African Americans. While the Northern colonies were more open and eventually opposed slavery altogether, the South colonies remained to be racist and did not want to see African Americans as people. This lead to very cruel overseers and many slaves being abused.
~Terrible conditions.
Slaves often lived in terrible conditions. Due to many plantation owners and overseers not caring about their well being, they would not give them much to work with, just the bare minimum. They did not want to spend their money on their slaves, so would build small shacks for them to live in. These were cold in the winter and as I mentioned above, very hot in the summer.