Question

Identify all statements that accurately describe the structure of the pyruvate dehydrogenase (PDH) complex.A. A regulatory kinase and phosphatase are part of the mammalian PDH complex. B. Several copies each fo E1 and E3 surround E2. C. E2 contains three domains. D. The complex contains multiplex is made up of several copies of E1.

Answer 1

Answer: Options A, B ,C and E are correct

Step-by-step explanation:

The structure of pyruvate dehydrogenase complex comprises if three enzymes E1, E2 and E3 which convert pyruvate to acetyl CoA. The three enzymes are have several copies.

Within the PDH complex, the E2 subunit forms the structural unit, contain three domains and are surrounded by E1 and E3. The E 2 accepts acetyl groups from E1 and transmit the group to coenzyme A. The decarboxylation of pyruvate and its conversion to acetyl-CoA by the PDH complex comes first before glucose carbon enter into the tricarboxylic acid (TCA) cycle. This process is important to the aerobic oxidation of glucose .