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How do mutations and natural selection lead to resistant populations of bacteria

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Answer:

Mutations are one way for bacteria to become resistant to antibiotics. Some spontaneous mutations (or genes that have been acquired from other bacteria through horizontal gene transfer) may make the bacterium resistant to an antibiotic (See: Resistance mechanisms for information about how bacteria resist antibiotic action). If we were to treat the bacterial population with that specific antibiotic, only the resistant bacteria will be able to multiply; the antibiotic selects for them. These bacteria can now increase in numbers and the end result is a population of mainly resistant bacteria.

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