Answer:
1. Because smallpox was a deadly disease which became eradicated thanks to Vaccination
2. People continued to die of smallpox in the 19th century either due to not being vaccinated or because their immune systems were already compromised before Vaccination. Some also reacted badly or not at all to the Vaccination so they ended up getting exposed to smallpox and dying, as Vaccination was not perfected and made safer in the 19th century as it is now.
Step-by-step explanation:
1. Jenner's Vaccination against smallpox was a major breakthrough because inoculation became the foundation for how epidemology and the prevention of disease would occur on a simple and larger scale, as well as provide a base and ability to reduce and/or eradicate other deadly diseases, especially things like Polio or Mumps.