20.8k views
4 votes
The amino acid substitution of Val for Glu in Hemoglobin S results in aggregation of the protein because of _____ interactions between molecules. covalent disulfide hydrogen bonding hydrophobic ionic

User Omalave
by
9.1k points

1 Answer

3 votes

Answer:

hydrophobic interactions

Step-by-step explanation:

Hemoglobin S (Hb S) is an abnormal type of hemoglobin where red blood cells become sickle-shaped and these elongated cells have difficulty to pass through small blood vessels. This type of hemoglobin is caused by a substitution (Glu>Val, GAG>GTG) in a β-globin gene variant. When the normal sequence is altered, a different amino acid is synthesized and it modifies the interactions between side chains by hydrophobic interactions, thereby affecting protein folding.

User Gordon Smyth
by
7.9k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.